精准医疗—纳米光学术中引导肿瘤诊断

报告人：徐剑助理教授（美国路易斯安娜州立大学）

报告时间：2019年5月13日（星期一）下午15:00

报告地点：万博体育bet 江浦校区浦江楼302会议室

报告摘要：

Surgical resection is the major treatment for solid tumors. The complete surgical resection of the cancer tissues in the surgery is essential to the prognosis of cancer patients. However, 40% of the US patients have the local recurrence in 5 years from the initial surgery, due to the failure to detect all the cancer tissues intraoperatively. In the surgery, in case of uncertainty, the surgeon may take biopsies and send for the frozen section procedure. This pathological procedure is expensive and inefficient: it may take 20-30 min while keeping the patient under anesthesia; due to the non-optimal preparation of the tissues, the diagnosis accuracy is lower than “formalin fixed paraffin embedded tissue procedure”. The latter procedure takes even longer time (several hours to days after the surgery) to obtain the diagnosis result.

Our lab developed an imaging system, together with ICG-protein complex as nano-imaging contrast agent, to help the intraoperative diagnosis of tissues. We have conducted dozens of clinical trials on human pancreatic cancer in major hospitals in USA. Over two hundred sample tissues from various pancreatic cancer surgeries, including distal pancreatectomy, Whipple procedure, and total pancreatectomy, were inspected with our imaging system. Within 1 sec, our device can quantitatively differentiate cancerous tissues from non-cancerous tissues intraoperatively: primary tumor and positive margins showed more than 200% stronger ICG fluorescence than normal tissues and negative margins did. The overall diagnosis accuracy of cancer by our system is 94.9%.

报告人简介：

徐剑，终身轨助理教授, 博导, 美国路易斯安娜州立大学, 电子与计算机工程系。

从事多领域交叉学科的研究，项目涉及电子、生物医学、光学工程、纳米技术、物理、化工等领域的交叉。主要研究重点在与多学科交叉的生物工程器件设计，这些器件主要瞄准两大类应用：1.模仿电鳗发电原理的污水发电器件；2.可用于精准引导肿瘤手术的光学医疗器械。两大类器件均取得很大成功，由其开发的后者，已经在美国几大医院投入临床试验，对于多种癌症（包括号称“癌症之王”-5年存活率仅有6%-的胰腺癌）有很高的快速诊断正确率，受到外科医生、病理学家和病人的广泛欢迎。其突破性成果多在《纽约科学院学报》（封面文章）、《ACS Omega》、《全球挑战》、《自然·纳米科技》、《先进材料》、《软物质》等被视为行业翘楚的国际权威杂志上发表。